Lymphocyte in vitro cytotoxicity: Mechanism of human lymphotoxin-induced target cell destruction

The role of lymphotoxin in target cell destruction by mitogen-activated human lymphocytes. I. The correlation of target cell sensitivity to lymphotoxin and the intact lymphocyte.

Role of Lymphotoxin in Target-cell Destruction Induced by Mitogen-activated Human Lymphocytes Invitro .2. Correlation of Temperature and Trypsin- Sensitive Phases of Lymphotoxin-induced and Lymphocyte-mediated Cytotoxicity

Lymphocyte-mediated Cytotoxicity in Vitro

The ability of antisera to suppress immune responses either in vivo or in vitro is well known. A variety of lymphocyte-target cell systems have been employed to demonstrate inhibition of cell-mediated immunity by antisera in vitro, and skin, tumor, and kidney graft survival have been prolonged by passively administered antiserum in vivo. An in vitro lymphocyte-tumor cell assay system was develo...

Antioxidant Effects of Pinus Eldarica Extracts Against Cisplatin-Induced Cytotoxicity in Human Hepatoma (Hepg2) Cell Line

Background:  Cisplatin has cytotoxic effects through free radical generation. Reports indicate that various members of Pinaceae family may have antioxidant properties. In this study we investigated the cytoprotective effects of needle volatile oil and bark extract of Pinus eldarica in hepatoma G2 (HepG2) cell line.  Methods: Using the maceration technique, we obtained the ethanolic extract of ...

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

A Lyt-2+, trinitrophenyl-specific, lymphotoxin-secreting, cytotoxic T-cell line, PCl 55, mediates the digestion of target cell DNA into discretely sized fragments. This phenomenon manifests itself within 30 min after effector cell encounter as measured by the release of 3H counts from target cells prelabeled with [3H]deoxythymidine and occurs even at very low effector to target cell ratios (0.2...